Molecular Weight: | 248.71 |
Formula: | C13H13ClN2O |
Purity: | ≥98% |
CAS#: | 49843-98-3 |
Solubility: | DMSO up to 50 mM |
Chemical Name: | 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:
EX-527 is a highly potent and selective inhibitor of SIRT1 with an IC50~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50~20-100 µM). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1.
How to Use:
Reference:
Xcess Biosciences,Inc.(XcessBio)由一群来自学术界和制药/生物技术行业的顶尖科学家于2008年成立,他们在药物化学,生物化学,分子和细胞生物学领域拥有丰富的专业知识。结合我们的合作者和顾问网络,我们致力于开发高质量的产品并提供最佳的服务,以满足生物医学研究中未满足的需求。
XcessBio的总部位于加利福尼亚州圣地亚哥,在最先进的研发设施中运营,设有化学合成实验室,分子和细胞生物学实验室以及分析质量控制实验室。
XcessBio一直为美国许多顶级制药,生物技术和试剂公司提供CRO服务和OEM产品,现在,我们将最好的产品和服务直接扩展到整个生命科学界。