| Molecular Weight: | 555.59 |
| Formula: | C29H32F3N5O3 |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide |
| Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.How to Use:In vitro:OICR9429 was used at 5-10 µM final concentration in various in vitro assays.In vivo: n/a Reference:
- 1.http://www.thesgc.org/chemical-probes/OICR-9429.
OICR9429_spec.pdfOICR9429_MSDS.pdf Xcess Biosciences，Inc.（XcessBio）由一群来自学术界和制药/生物技术行业的顶尖科学家于2008年成立，他们在药物化学，生物化学，分子和细胞生物学领域拥有丰富的专业知识。结合我们的合作者和顾问网络，我们致力于开发高质量的产品并提供最佳的服务，以满足生物医学研究中未满足的需求。
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XcessBio一直为美国许多顶级制药，生物技术和试剂公司提供CRO服务和OEM产品，现在，我们将最好的产品和服务直接扩展到整个生命科学界。
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