| Molecular Weight: | 398.48 |
| Formula: | C22H22N2O4S |
| Purity: | ≥98% |
| CAS#: | 309928-48-1 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 1-(9H-carbazol-9-yl)-5-(furan-2-yl)-4-(methylsulfonyl)pentan-2-ol |
| Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:
KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring aBmal1-dLucluciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.
How to Use:
- In vitro: KL001 was used at 10-50 µM in vitro and in cellular assays.
- In vivo:n/a
Reference:
- 1. Hirota T, et al. Identification of Small Molecule Activators of Cryptochrome. (2012) Science 337(6098):1094-7.
KL001_spec.pdf- KL001_MSDS.pdf
Products are for research use only. Not for human use. |
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